Viera Margarita, Davis-McGibony C Michele
Department of Chemistry, Georgia Southern University, Statesboro, GA 30460-8064, USA.
Protein J. 2008 Sep;27(6):371-5. doi: 10.1007/s10930-008-9146-z.
Chromodulin (also known as low-molecular-weight chromium-binding substance, LMWCr) is a chromium-binding oligopeptide proposed to play a role in insulin signaling and chromium transport in mammals. This laboratory has isolated and purified this material from a non-mammalian source, an avian. Spectroscopic and physical characterization of the isolated material suggests the material is an oligopeptide with a multinuclear chromium assembly bridged via asparatate and glutamate residues very similar to its mammalian counterparts. The isolated material also possesses a biological activity similar to other LMWCr isolates.
铬调素（也称为低分子量铬结合物质，LMWCr）是一种铬结合寡肽，被认为在哺乳动物的胰岛素信号传导和铬运输中发挥作用。本实验室已从非哺乳动物来源——禽类中分离并纯化了这种物质。对分离出的物质进行光谱和物理特性分析表明，该物质是一种寡肽，具有通过天冬氨酸和谷氨酸残基桥接的多核铬组装体，与其哺乳动物对应物非常相似。分离出的物质还具有与其他LMWCr分离物相似的生物活性。
