Bagnell C A
Department of Animal Sciences, Cook College, Rutgers University, New Brunswick, New Jersey 08903.
Steroids. 1991 May;56(5):242-6. doi: 10.1016/0039-128x(91)90041-s.
The studies described here support the concept that relaxin is a product of the ovarian follicle and interacts with systemic hormones in the local regulation of the ovary. This report reviews the work indicating that relaxin is a product of the ovarian follicle and presents evidence for the biologic action of relaxin within the follicle. Production of relaxin by cells of the theca interna was given support by immunocytochemical localization work, in vitro production studies, and detection of relaxin mRNA by in situ hybridization. The relaxin content of porcine follicular fluid was shown to increase with development induced by gonadotropins. During thecal cell culture, luteinizing hormone and porcine follicular fluid increased relaxin secretion, whereas the presence of granulosa cells was without effect. A biologic action for relaxin on connective tissue remodeling was supported by an increase in follicle-stimulating hormone-stimulated plasminogen activator activity by granulosa cells. Additional work is needed to investigate the possibility of other roles for relaxin within the follicle, to identify relaxin receptors, and to explore the interaction of relaxin with endocrine and other paracrine factors in the ovary.
此处所述的研究支持这样一种概念，即松弛素是卵巢卵泡的产物，并在卵巢的局部调节中与全身激素相互作用。本报告回顾了表明松弛素是卵巢卵泡产物的相关研究工作，并提供了松弛素在卵泡内生物学作用的证据。免疫细胞化学定位研究、体外生产研究以及原位杂交检测松弛素mRNA等工作均支持卵泡内膜细胞产生松弛素这一观点。猪卵泡液中的松弛素含量显示随着促性腺激素诱导的卵泡发育而增加。在卵泡膜细胞培养过程中，促黄体生成素和猪卵泡液可增加松弛素的分泌，而颗粒细胞的存在则无影响。颗粒细胞对促卵泡激素刺激的纤溶酶原激活物活性增加，支持了松弛素对结缔组织重塑具有生物学作用这一观点。还需要进一步开展工作，以研究松弛素在卵泡内其他作用的可能性、鉴定松弛素受体，并探索松弛素与卵巢内分泌及其他旁分泌因子之间的相互作用。
