通过晚期糖基化终末产物可溶性受体（sRAGE）检测母婴感染/炎症：一项初步研究的结果

Detection of feto-maternal infection/inflammation by the soluble receptor for advanced glycation end products (sRAGE): results of a pilot study.

作者信息

Hájek Zdenek, Germanová Anna, Koucký Michal, Zima Tomás, Kopecký Pavel, Vítkova Marie, Parízek Antonín, Kalousová Marta

机构信息

Department of Obstetrics and Gynecology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.

出版信息

J Perinat Med. 2008;36(5):399-404. doi: 10.1515/JPM.2008.080.

DOI:10.1515/JPM.2008.080

PMID:18771410

Abstract

OBJECTIVE

The receptor for advanced glycation end products, RAGE, plays an important role in the pathogenesis of several diseases. sRAGE, soluble receptor for advanced glycation end products, is an inhibitor of the pathological effect mediated via RAGE. The aim of this study was to assess the usefulness of measuring sRAGE concentration in pregnant women with threatening preterm labor.

METHODS

Serum levels of sRAGE, interleukin-6 (IL-6) and routine markers of inflammation were determined in 46 pregnant women with threatening preterm labor, 35 healthy pregnant women and 15 non-pregnant controls.

RESULTS

Serum levels of sRAGE in healthy pregnant women were significantly lower than in non-pregnant controls (669+/-296 vs. 1929+/-727 pg/mL, P<0.05). Women with threatening preterm birth had a significantly higher concentration of serum sRAGE in comparison with healthy pregnant women (819+/-329 pg/mL vs. 669+/-296 pg/mL, P<0.05). Conversely, patients with PPROM had significantly lower levels of sRAGE compared with patients with threatening premature labor (600+/-324 pg/mL, P<0.05). sRAGE correlated negatively with leukocyte counts (r=-0.325, P<0.05).

CONCLUSIONS

sRAGE might be a new and promising marker of premature labor, especially with the symptoms of PPROM.

摘要

目的

晚期糖基化终末产物受体（RAGE）在多种疾病的发病机制中起重要作用。可溶性晚期糖基化终末产物受体（sRAGE）是经由RAGE介导的病理效应的抑制剂。本研究的目的是评估测定有先兆早产孕妇血清中sRAGE浓度的实用性。

方法

测定46例有先兆早产孕妇、35例健康孕妇和15例非孕对照者血清中sRAGE、白细胞介素-6（IL-6）水平及常规炎症标志物水平。

结果

健康孕妇血清sRAGE水平显著低于非孕对照者（669±296 vs. 1929±727 pg/mL，P<0.05）。有先兆早产的孕妇血清sRAGE浓度显著高于健康孕妇（819±329 pg/mL vs. 669±296 pg/mL，P<0.05）。相反，胎膜早破患者的sRAGE水平显著低于有先兆早产的患者（600±324 pg/mL，P<0.05）。sRAGE与白细胞计数呈负相关（r=-0.325，P<0.05）。