Rzepka Rafał, Dołęgowska Barbara, Rajewska Aleksandra, Kwiatkowski Sebastian
Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland.
Mediators Inflamm. 2014;2014:251451. doi: 10.1155/2014/251451. Epub 2014 Dec 8.
Preterm labour is defined as a birth taking place between 22nd and 37th weeks of gestation. Despite numerous studies on the aetiology and pathogenesis of preterm labour, its very cause still remains unclear. The importance of the cytokines and acute inflammation in preterm labour aetiology is nowadays well-proven. However, chronic inflammation as an element of the pathogenesis of premature labour is still unclear. This paper presents a literature review on the damage-associated molecular patterns (DAMPs), receptors for advanced glycation end products (RAGE), negative soluble isoforms of RAGE, chemokine-stromal cell-derived factor-1 (SDF-1) and one of the adipokines, resistin, in the pathogenesis of preterm labour. We conclude that the chronic inflammatory response can play a much more important role in the pathogenesis of preterm delivery than the acute one.
早产被定义为妊娠22至37周之间发生的分娩。尽管对早产的病因和发病机制进行了大量研究，但其确切原因仍不清楚。细胞因子和急性炎症在早产病因中的重要性如今已得到充分证实。然而，慢性炎症作为早产发病机制的一个因素仍不明确。本文对损伤相关分子模式（DAMPs）、晚期糖基化终末产物受体（RAGE）、RAGE的负性可溶性异构体、趋化因子基质细胞衍生因子-1（SDF-1）以及脂肪因子之一的抵抗素在早产发病机制中的作用进行了文献综述。我们得出结论，慢性炎症反应在早产发病机制中可能比急性炎症反应发挥更重要的作用。
