马查多-约瑟夫病的睡眠症状及其临床关联
Sleep symptoms and their clinical correlates in Machado-Joseph disease.
作者信息
D'Abreu A, França M, Conz L, Friedman J H, Nucci A M, Cendes F, Lopes-Cendes I
机构信息
University of Campinas, Brazil.
出版信息
Acta Neurol Scand. 2009 Apr;119(4):277-80. doi: 10.1111/j.1600-0404.2008.01092.x. Epub 2008 Sep 3.
OBJECTIVE
To evaluate the presence of sleep symptoms in Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3).
SUBJECTS/METHODS: We used a sleep questionnaire and the Epworth Sleepiness Scale to compare 53 patients with MJD/SCA3 and 106 controls.
RESULTS
Patients with MJD/SCA3 reported more symptoms of insomnia, restless leg syndrome and REM sleep behavior disorder as well as nocturnal cramps, snoring and nocturnal apnea. Insomnia was the most frequently reported sleep-related complaint in the MJD/SCA3 group.
CONCLUSIONS
Our results indicate that sleep disorders are common in patients with MJD/SCA3 and probably have a multifactorial etiology, with components of a primary sleep disorder in addition to sleep-disrupting symptoms such as nocturia and cramps.
目的
评估马查多-约瑟夫病/3型脊髓小脑共济失调（MJD/SCA3）患者睡眠症状的存在情况。
受试者/方法：我们使用一份睡眠问卷和爱泼沃斯思睡量表，对53例MJD/SCA3患者和106名对照者进行比较。
结果
MJD/SCA3患者报告有更多的失眠、不宁腿综合征和快速眼动睡眠行为障碍症状，以及夜间抽筋、打鼾和夜间呼吸暂停。失眠是MJD/SCA3组中最常报告的与睡眠相关的主诉。
结论
我们的结果表明，睡眠障碍在MJD/SCA3患者中很常见，其病因可能是多因素的，除夜尿症和抽筋等干扰睡眠的症状外，还存在原发性睡眠障碍的成分。
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