D'Abreu Anelyssa, Friedman Joseph, Coskun Jim
Department of Neurology, Memorial Hospital of Rhode Island, 111 Brewster Street, Pawtucket, RI 02860, USA.
Mov Disord. 2005 Jun;20(6):739-41. doi: 10.1002/mds.20419.
We describe three patients with the Machado-Joseph disease (MJD) genetic abnormality who had non-movement disorder neurological symptoms or signs that preceded the gait ataxia by several years. This implies that some clinical manifestations other than ataxia may be considered part of the herald symptoms of MJD, especially in the setting of a positive family history.
我们描述了三名患有Machado-Joseph病（MJD）基因异常的患者，他们在步态共济失调出现前数年就有非运动障碍性神经症状或体征。这意味着共济失调以外的一些临床表现可能被视为MJD先兆症状的一部分，尤其是在有阳性家族史的情况下。
