广谱抗生素预防对剖宫产术后手术伤口感染发生率的影响。

Impact of extended-spectrum antibiotic prophylaxis on incidence of postcesarean surgical wound infection.

作者信息

Tita Alan T N, Owen John, Stamm Alan M, Grimes Anne, Hauth John C, Andrews William W

机构信息

Center for Women's Reproductive Health, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.

出版信息

Am J Obstet Gynecol. 2008 Sep;199(3):303.e1-3. doi: 10.1016/j.ajog.2008.06.068.

DOI:10.1016/j.ajog.2008.06.068

PMID:18771992

Abstract

OBJECTIVE

We assessed the impact of an extended-spectrum antibiotic prophylaxis regimen (azithromycin in addition to recommended narrow-spectrum cephalosporin) on postcesarean incisional wound infection.

STUDY DESIGN

Data from prospective surveillance of surgical site infections at our institution were used to compare incidence in postcesarean incisional wound infection for 3 consecutive time periods of antibiotic prophylaxis: (1) standard (ie, cephalosporin only, 1992-1996); (2) clinical trial of extended spectrum (ie, extended vs cephalosporin only, 1997-1999); and (3) routine use of extended spectrum (2001-2006).

RESULTS

The incidence of postcesarean incisional wound infections decreased progressively from 3.1% to 2.4% and then to 1.3% over the 3 consecutive periods (P value for trend < .002).

CONCLUSION

Increasing the use of extended-spectrum antibiotic prophylaxis at our institution over 3 time periods was associated with a decreasing trend in postcesarean incisional wound infection.

摘要

目的

我们评估了一种广谱抗生素预防方案（除推荐的窄谱头孢菌素外，加用阿奇霉素）对剖宫产术后切口感染的影响。

研究设计

利用我们机构对手术部位感染进行前瞻性监测的数据，比较连续3个抗生素预防时间段剖宫产术后切口感染的发生率：（1）标准方案（即仅使用头孢菌素，1992 - 1996年）；（2）广谱抗生素临床试验（即广谱抗生素与仅用头孢菌素对比，1997 - 1999年）；以及（3）广谱抗生素常规使用阶段（2001 - 2006年）。