Penrod Joan D, Litke Ann, Hawkes William G, Magaziner Jay, Doucette John T, Koval Kenneth J, Silberzweig Stacey B, Egol Kenneth A, Siu Albert L
Geriatric Research, Eeducation, and Clinical Center, James J. Peters VA Medical Center, 130 Kingsbridge Road, Bronx, NY 10468, USA.
J Gerontol A Biol Sci Med Sci. 2008 Aug;63(8):867-72. doi: 10.1093/gerona/63.8.867.
Few studies of hip fracture have large enough samples of men, minorities, and persons with specific comorbidities to examine differences in their mortality and functional outcomes. To address this problem, we combined three cohorts of hip fracture patients to produce a sample of 2692 patients followed for 6 months.
Data on mortality, mobility, and other activities of daily living (ADLs) were available from all three cohorts. We used multiple regression to examine the association of race, gender, and comorbidity with 6-month survival and function, controlling for prefracture mobility and ADLs, age, fracture type, cohort, and admission year.
The mortality rate at 6 months was 12%: 9% for women and 19% for men. Whites and women were more likely than were nonwhites and men to survive to 6 months, after adjusting for age, comorbidities, and prefracture mobility and function. Whites were more likely than were nonwhites to walk independently or with help at 6 months compared to not walking, after adjusting for age, comorbidities, and prefracture mobility and function. Dementia had a negative impact on survival, mobility, and ADLs at 6 months. The odds of survival to 6 months were significantly lower for people with chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF), and/or cancer. Parkinson's disease and stroke had negative impacts on mobility and ADLs, respectively, among survivors at 6 months.
The finding of higher mortality and worse mobility for nonwhite patients with hip fractures highlights the need for more research on race/ethnicity disparities in hip fracture care.
很少有关于髋部骨折的研究拥有足够大的男性、少数族裔以及患有特定合并症患者的样本,以检验他们在死亡率和功能结局方面的差异。为了解决这一问题,我们合并了三个髋部骨折患者队列,形成了一个2692例患者的样本,并对其进行了6个月的随访。
所有三个队列均提供了关于死亡率、活动能力以及其他日常生活活动(ADL)的数据。我们使用多元回归分析来检验种族、性别和合并症与6个月生存率和功能之间的关联,并对骨折前的活动能力和ADL、年龄、骨折类型、队列以及入院年份进行了控制。
6个月时的死亡率为12%:女性为9%,男性为19%。在对年龄、合并症以及骨折前的活动能力和功能进行调整后,白人和女性比非白人和男性更有可能存活至6个月。在对年龄、合并症以及骨折前的活动能力和功能进行调整后,与无法行走相比,白人在6个月时更有可能独立行走或在他人帮助下行走。痴呆对6个月时的生存、活动能力和ADL有负面影响。患有慢性阻塞性肺疾病(COPD)、充血性心力衰竭(CHF)和/或癌症的患者存活至6个月的几率显著较低。帕金森病和中风分别对6个月时幸存者的活动能力和ADL有负面影响。
髋部骨折的非白人患者死亡率较高且活动能力较差这一发现凸显了对髋部骨折护理中种族/族裔差异进行更多研究的必要性。