Vinciguerra Manlio, Foti Michelangelo
Dept. Cellular Physiology and Metabolism, Geneva Medical Faculty, Geneva, Switzerland.
Ann Hepatol. 2008 Jul-Sep;7(3):192-9.
The tumor suppressor PTEN is a phosphoinositide phosphatase regulating the PI3K/Akt signaling pathways and mutated or deleted in a variety of human cancers. Recent evidence indicates that dysregulated PTEN expression and activity in the liver critically affect hepatic insulin sensitivity and trigger the development of non-alcoholic fatty liver diseases. As well, PTEN expression/activity is also affected with HBV and HCV infection, or following alcohol-related injury. Finally, PTEN mutations/deletions or low PTEN expression are associated with diverse liver malignancies thus suggesting a critical role for PTEN in hepatic cancers. This review will focus on our current knowledge of the regulation of PTEN expression/activity and the role of this phosphatase in liver diseases.
肿瘤抑制因子PTEN是一种磷酸肌醇磷酸酶，可调节PI3K/Akt信号通路，在多种人类癌症中发生突变或缺失。最近的证据表明，肝脏中PTEN表达和活性失调会严重影响肝脏胰岛素敏感性，并引发非酒精性脂肪性肝病的发展。此外，PTEN的表达/活性也会受到HBV和HCV感染或酒精相关损伤的影响。最后，PTEN突变/缺失或低PTEN表达与多种肝脏恶性肿瘤相关，这表明PTEN在肝癌中起关键作用。本综述将聚焦于我们目前对PTEN表达/活性调控的认识以及这种磷酸酶在肝脏疾病中的作用。
