Kelemen Linda E, Sellers Thomas A, Vachon Celine M
Department of Population Health Research, Alberta Cancer Board, 1,331 29th Street North West, Calgary, Alberta T2N 4N2, Canada.
Nat Rev Cancer. 2008 Oct;8(10):812-23. doi: 10.1038/nrc2466. Epub 2008 Sep 5.
Mammographic density (MD) reflects variations in fat, stromal and epithelial tissues that are thought to be regulated by several genes. High MD is an established risk factor for breast cancer; therefore, genes that regulate MD may indirectly influence breast cancer. These genes might also be fewer in number and easier to identify than those for breast cancer risk outside of inherited predisposition syndromes. In this Perspective, we review the limited genetic studies of MD and propose future directions.
乳腺密度(MD)反映了脂肪、基质和上皮组织的变化,这些组织被认为受多个基因调控。高乳腺密度是乳腺癌的一个既定风险因素;因此,调控乳腺密度的基因可能间接影响乳腺癌。与遗传性易感性综合征之外的乳腺癌风险相关基因相比,这些基因的数量可能更少,也更容易识别。在这篇观点文章中,我们回顾了关于乳腺密度的有限基因研究,并提出了未来的研究方向。