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[与深静脉血栓形成部位相关的肺栓塞发病率及症状学]

[Incidence and symptomatology of lung embolism in relation to the site of deep venous thrombosis].

作者信息

Stiegler H, Weichenhain B, Chatzopulos D, Mathies R, Standl R, Standl E, Mehnert H

机构信息

Forschergruppe Diabetes, Schwabinger Krankenhauses.

出版信息

Vasa. 1991;20(2):119-24.

PMID:1877330
Abstract

The uncertainty about the true incidence of pulmonary embolism (PE) in connection with deep venous thrombosis (DVT) becomes evident when comparing the results of autopsy--vs. clinical studies, with the former showing a three-fold elevated rate of embolisation. In order to evaluate the percentage of clinically inapparent PE, all patients (65 females, 54 males, mean age 61.3 years) hospitalized between April 1989 and March 1990 with suspected DVT and/or PE underwent duplex-sonography and pulmonary scintigraphy. In 108 cases, DVT could be ascertained, whereas 11 patients only suffered from PE. In 57.4% of all DVT, PE was diagnosed. Of the 73 cases with PE, only 53.4% of the patient stated typical symptoms primarily. In more than 1/4 of the patients with primary symptoms of PE, no DVT could be diagnosed. There was no significant difference between the occurrence of PE in relation to the localisation of DVT, with 1/3 to 1/2 being asymptomatic. 1/4 of the patients with leg-thrombosis and 1/7 with thrombosis of the iliac vein did not complain of typical symptoms of thrombosis. Furthermore, an increased PE-rate seems to occur with an elevated ultrasound echogenity of the thrombus. As a result of the study pulmonary szintigrams seem to be indicated in all cases of DVT in order to evaluate the total PE risk.

摘要

当比较尸检结果与临床研究结果时,肺栓塞(PE)与深静脉血栓形成(DVT)相关的真实发病率的不确定性变得明显,前者显示栓塞率提高了三倍。为了评估临床隐匿性PE的百分比,对1989年4月至1990年3月期间因疑似DVT和/或PE住院的所有患者(65名女性,54名男性,平均年龄61.3岁)进行了双功超声检查和肺闪烁扫描。在108例中可确定为DVT,而11例仅患有PE。在所有DVT中,57.4%被诊断出患有PE。在73例患有PE的患者中,只有53.4%的患者主要表现出典型症状。在超过四分之一有PE主要症状的患者中,未诊断出DVT。PE的发生与DVT的部位之间没有显著差异,三分之一至二分之一为无症状。四分之一的腿部血栓患者和七分之一的髂静脉血栓患者没有诉说典型的血栓症状。此外,随着血栓超声回声性的升高,PE发生率似乎也会增加。研究结果表明,为了评估总的PE风险,在所有DVT病例中似乎都应进行肺闪烁扫描。

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