阐明单胺氧化酶B抑制剂的作用机制及潜在相互作用。

Elucidating the mechanism of action and potential interactions of MAO-B inhibitors.

作者信息

Bainbridge Jacquelyn L, Page Robert Lee, Ruscin J Mark

机构信息

Department of Clinical Pharmacy, University of Colorado-Aurora, 12631 East 17th Avenue, Aurora, CO 80045, USA.

出版信息

Neurol Clin. 2008 Aug;26(3 Suppl):S85-96, vi. doi: 10.1016/j.ncl.2008.05.002.

DOI:10.1016/j.ncl.2008.05.002

PMID:18774444

Abstract

A critical enzyme in neurotransmitter metabolism is monoamine oxidase (MAO). MAO occurs in two isoforms, MAO-A and MAO-B. MAO inhibitors are classified as selective for a particular subtype of MAO or nonselective and can be reversible or irreversible. Nonselective MAO inhibitors originally were studied as antidepressants. Newer MAO-B selective irreversible inhibitors are indicated for use in treatment of Parkinson's disease. MAO-B inhibitors offer modest antiparkinsonian effects, as they do not inhibit brain MAO-A effectively at the dose used in treating Parkinson's disease. In this article, the mechanism of action of MAO-B inhibitors, their potential neuroprotective effects, interactions such as the cheese reaction, and serotonin syndrome are discussed.

摘要

神经递质代谢中的一种关键酶是单胺氧化酶（MAO）。MAO有两种同工型，即MAO-A和MAO-B。MAO抑制剂分为对特定MAO亚型具有选择性或非选择性的，并且可以是可逆的或不可逆的。非选择性MAO抑制剂最初作为抗抑郁药进行研究。新型MAO-B选择性不可逆抑制剂被用于治疗帕金森病。MAO-B抑制剂具有适度的抗帕金森病作用，因为在治疗帕金森病所用的剂量下，它们不能有效抑制脑MAO-A。本文讨论了MAO-B抑制剂的作用机制、其潜在的神经保护作用、诸如奶酪反应等相互作用以及5-羟色胺综合征。