Hermanova Marketa, Vitezslav Vit, Husicka Richard, Neumanova Renata, Pacik Dalibor
Department of Pathology, Masaryk University and University Hospital, 625 00 Brno, Czech Republic.
Ann Diagn Pathol. 2008 Oct;12(5):365-7. doi: 10.1016/j.anndiagpath.2007.01.007. Epub 2007 Oct 29.
Primary transitional cell carcinoma (TCC) of the vagina represents an extremely rare neoplasm and is associated with multicentric TCC of the urinary tract in all described cases. A case of multicentric TCC of the vagina and the left ureter in a 73-year-old woman is reported. Immunohistochemical analysis of cytokeratin expression was performed. Immunohistochemistry proved to play an important role in the differential diagnosis of vaginal TCC, supported the morphological diagnosis of TCC, and largely excluded the diagnosis of vaginal papillary carcinoma with transitional features as a morphological variant of squamous cell carcinoma. Subsequent urological examination revealed multicentric TCC of the left ureter. During the follow up, the metastases of the vaginal TCC into the regional inguinal lymph nodes were diagnosed, suggesting that indolent clinical course is not a rule in this type of tumor.
原发性阴道移行细胞癌（TCC）极为罕见，在所有已报道的病例中均与泌尿道多中心TCC相关。本文报道了一例73岁女性阴道和左输尿管多中心TCC病例。对细胞角蛋白表达进行了免疫组织化学分析。免疫组织化学在阴道TCC的鉴别诊断中发挥了重要作用，支持了TCC的形态学诊断，并在很大程度上排除了具有移行特征的阴道乳头状癌作为鳞状细胞癌形态学变异的诊断。随后的泌尿外科检查发现左输尿管多中心TCC。随访期间，诊断出阴道TCC转移至区域腹股沟淋巴结，提示这种类型的肿瘤并非都具有惰性临床病程。
