Mulayim Baris, Celik Nilufer Y, Onalan Gogsen, Zeyneloglu Hulusi B, Kuscu Esra
Department of Obstetrics and Gynecology, Alanya, Turkey.
Fertil Steril. 2009 Aug;92(2):678-81. doi: 10.1016/j.fertnstert.2008.07.1706. Epub 2008 Sep 6.
To assess the efficacy of sublingual misoprostol after surgical management of early termination of pregnancy (ETP) regarding duration and amount of bleeding, presence of retained products of conception (RPOC), and endometrial thickness.
Prospective, randomized clinical trial.
University hospital.
PATIENT(S): One hundred five patients admitted for possible management of early pregnancy failure and unwanted pregnancy.
INTERVENTION(S): Manual vacuum aspiration (control and study groups) plus 400 microg sublingual misoprostol (study group) at pregnancy termination, and transvaginal ultrasonography (both groups) 10 days after the procedure.
MAIN OUTCOME MEASURE(S): Duration and amount of bleeding and presence of RPOC and endometrial thickness 10 days after the procedure.
RESULT(S): Bleeding lasted 3.2 and 5.1 days in the study and control groups. Severe vaginal bleeding occurred in two patients in the study group and in six patients in the control group. Mean endometrial thickness was 5.5 mm in the study group and 6.9 mm in the control group. These differences were statistically significant. No cases of RPOC occurred in the study group; two cases occurred in the control group.
CONCLUSION(S): In countries in which surgical management of ETP is still done, using sublingual misoprostol postoperatively may reduce the duration and amount of bleeding.
评估在早期终止妊娠（ETP）手术处理后，舌下含服米索前列醇在出血持续时间和出血量、妊娠物残留（RPOC）情况以及子宫内膜厚度方面的疗效。
前瞻性随机临床试验。
大学医院。
105例因早期妊娠失败和意外妊娠可能需要处理而入院的患者。
妊娠终止时，人工负压吸引术（对照组和研究组）加舌下含服400微克米索前列醇（研究组），术后10天两组均行经阴道超声检查。
术后10天的出血持续时间和出血量、RPOC情况以及子宫内膜厚度。
研究组和对照组的出血分别持续3.2天和5.1天。研究组有2例患者发生严重阴道出血，对照组有6例。研究组平均子宫内膜厚度为5.5毫米，对照组为6.9毫米。这些差异具有统计学意义。研究组未发生RPOC病例；对照组发生2例。
在仍采用手术方式处理ETP的国家，术后使用舌下含服米索前列醇可能会减少出血的持续时间和出血量。
