全部阻断：β-抑制蛋白抑制细胞信号传导。
Blocking them all: beta-arrestins inhibit cellular signaling.
作者信息
Lohse Martin J, Klenk Christoph
机构信息
Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Strasse 9, 97078 Würzburg, Germany.
出版信息
Mol Cell. 2008 Sep 5;31(5):619-21. doi: 10.1016/j.molcel.2008.08.015.
PMID:18775321
Abstract
beta-arrestins are scaffold proteins that link G protein-coupled receptors to multiple "nonclassical" signaling pathways. In this issue of Molecular Cell, Mo et al. (2008) show that beta-arrestin1 also switches off signaling through the STAT1 transcription factor, thereby inhibiting interferon-induced antiviral responses.
摘要
β-抑制蛋白是一种支架蛋白，可将G蛋白偶联受体与多种“非经典”信号通路相连。在本期《分子细胞》杂志中，Mo等人（2008年）表明，β-抑制蛋白1还可通过信号转导和转录激活因子1（STAT1）转录因子关闭信号传导，从而抑制干扰素诱导的抗病毒反应。
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