6-Aryl- and 6-heteroarylpurines via cyclotrimerization.

作者信息

Turek Pavel, Hocek Michal, Kotora Martin

机构信息

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.

出版信息

Nucleic Acids Symp Ser (Oxf). 2008(52):533-4. doi: 10.1093/nass/nrn270.

DOI:10.1093/nass/nrn270

PMID:18776489

Abstract

Transition metal complex catalysed cocyclotrimerization of 6-alkynylpurines 1 with various diynes 2 and 6-(diynyl)purines 4 with nitriles 5 enabled to synthesize series of substituted 6-arylpurines 3 and 6-heteroarylpurines 6 in good yields. The obtained 6-aryl- and 6-heteroarylpurines were tested for cytostatic activity.

摘要