通过环三聚反应合成6-芳基嘌呤和6-杂芳基嘌呤。
6-Aryl- and 6-heteroarylpurines via cyclotrimerization.
作者信息
Turek Pavel, Hocek Michal, Kotora Martin
机构信息
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
出版信息
Nucleic Acids Symp Ser (Oxf). 2008(52):533-4. doi: 10.1093/nass/nrn270.
PMID:18776489
Abstract
Transition metal complex catalysed cocyclotrimerization of 6-alkynylpurines 1 with various diynes 2 and 6-(diynyl)purines 4 with nitriles 5 enabled to synthesize series of substituted 6-arylpurines 3 and 6-heteroarylpurines 6 in good yields. The obtained 6-aryl- and 6-heteroarylpurines were tested for cytostatic activity.
摘要
过渡金属配合物催化6-炔基嘌呤1与各种二炔2的共环三聚反应以及6-(二炔基)嘌呤4与腈5的反应，能够以良好的产率合成一系列取代的6-芳基嘌呤3和6-杂芳基嘌呤6。对所得到的6-芳基嘌呤和6-杂芳基嘌呤进行了细胞生长抑制活性测试。
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