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含有3'-O,4'-C-亚丙基腺苷作为强效核糖核酸酶L激动剂的生物活性2-5A类似物。

Biologically active 2-5A analogs containing 3'-O,4'-C-propylene adenosine as potent RNase L agonists.

作者信息

Morita Koji, Obika Satoshi, Imanishi Takeshi, Kitade Yukio, Koizumi Makoto

机构信息

Formulation Technology Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo 140-8710, Japan.

出版信息

Nucleic Acids Symp Ser (Oxf). 2008(52):637-8. doi: 10.1093/nass/nrn322.

DOI:10.1093/nass/nrn322
PMID:18776541
Abstract

Novel 2-5A analogs composed of 3'-O, 4'-C-alkylene adenosine were synthesized as potent RNase L activators. When we examined their properties, including their RNase L activating ability and their stability to exonuclease, we found that these 2-5A analogs showed high RNase L activation and high resistance to enzymatic degradation without the modification of an essential adenosine at the second position.

摘要

合成了由3'-O，4'-C-亚烷基腺苷组成的新型2-5A类似物作为有效的RNase L激活剂。当我们研究它们的性质，包括它们的RNase L激活能力和对外切核酸酶的稳定性时，我们发现这些2-5A类似物在不修饰第二个位置的必需腺苷的情况下表现出高RNase L激活和对酶促降解的高抗性。

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