使用SIENAX和SIENA对多发性硬化症脑萎缩测量中不同输入图像类型之间的一致性

Agreement between different input image types in brain atrophy measurement in multiple sclerosis using SIENAX and SIENA.

作者信息

Neacsu Veronica, Jasperse Bas, Korteweg Tijmen, Knol Dirk L, Valsasina Paola, Filippi Massimo, Barkhof Frederik, Rovaris Marco, Vrenken Hugo

机构信息

MS Center Amsterdam, VU University Medical Center, Department of Radiology, Amsterdam, The Netherlands.

出版信息

J Magn Reson Imaging. 2008 Sep;28(3):559-65. doi: 10.1002/jmri.21501.

DOI:10.1002/jmri.21501

PMID:18777529

Abstract

PURPOSE

To investigate whether multiple sclerosis (MS) atrophy can be assessed by SIENA and SIENAX software using other image types from MS research protocols than T1-weighted images without contrast agent, which are not always available.

MATERIALS AND METHODS

We selected 46 MS patients with identical magnetic resonance imaging (MRI) protocols at two timepoints. We calculated normalized brain volume (NBV) using SIENAX, and percentage brain volume change (PBVC) using SIENA, from T1-weighted images with and without contrast agent, T2-weighted images, and (calculated) pseudo-T1-weighted images. Relative agreement of the results was assessed using variance component estimation.

RESULTS

Relative agreement with T1-weighted images without contrast agent was good for T1-weighted images with contrast agent (ICC=0.86 for NBV, ICC=0.77 for PBVC), and reasonably good for pseudo-T1 and T2-weighted images (T2: ICC=0.72 for NBV, 0.58 for PBVC; pseudo-T1: ICC=0.68 for NBV, 0.83 for PBVC).

CONCLUSION

Brain atrophy can be studied using SIENA and SIENAX if T1-weighted images without contrast agent are not available. T1-weighted images with contrast agent should be used if available. Otherwise, pseudo-T1 and T2-weighted images seem acceptable and accessible alternatives. The use of these other images will greatly improve research possibilities, especially regarding older datasets.

摘要

目的

研究对于多发性硬化症（MS）萎缩情况，能否使用SIENA和SIENAX软件，通过多发性硬化症研究方案中的其他图像类型（而非总是难以获取的无造影剂T1加权图像）进行评估。

材料与方法

我们选取了46例在两个时间点采用相同磁共振成像（MRI）方案的MS患者。我们使用SIENAX计算标准化脑容量（NBV），并使用SIENA计算脑容量变化百分比（PBVC），图像类型包括有无造影剂的T1加权图像、T2加权图像以及（计算得到的）伪T1加权图像。结果的相对一致性通过方差成分估计进行评估。

结果

对于无造影剂的T1加权图像，有造影剂的T1加权图像与之相对一致性良好（NBV的组内相关系数ICC = 0.86，PBVC的ICC = 0.77），伪T1加权图像和T2加权图像与之相对一致性也较好（T2加权图像：NBV的ICC = 0.72，PBVC的ICC = 0.58；伪T1加权图像：NBV的ICC = 0.68，PBVC的ICC = 0.83）。