Ben Bashat Dafna, Sivan Ida, Ziv Michal, Aizenstein Orna, Pianka Pazit, Malach Rafael, Graif Moshe, Hendler Talma, Navon Gil
The Functional Brain Imaging Center, The Wohl Institute for Advanced Imaging, Department of Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. dafnab@;tasmc.health.gov.il
J Magn Reson Imaging. 2008 Nov;28(5):1245-50. doi: 10.1002/jmri.21587.
To assess the applicability of T1-weighted images in the presence of a contrast agent for functional mapping free of susceptibility artifacts, in comparison to the blood oxygenation level-dependent (BOLD) imaging.
Six patients and five control subjects were scanned using BOLD and T1-weighted functional imaging, in the presence of a Gd-DTPA contrast-agent (TOFICA). In the control group, low- and high-resolution BOLD images were performed. Functional stimuli included motor and language activations.
Both BOLD and TOFICA methods resulted in activations in the expected anatomical regions. The TOFICA mapping gave less distributed and with higher percent signal changes in comparison with the BOLD images. Gd-DTPA remained almost constant in the blood for at least 15 min post injection. In one patient with surgical clips, no signal was detected in the left cerebral hemisphere using BOLD imaging, but activation could be mapped using the TOFICA method.
T1-weighted imaging in the presence of a contrast agent can be used for functional mapping. This method is insensitive to susceptibility artifacts, and is therefore advantageous in the evaluation of presurgical cases and in areas of the brain close to cavities in which the BOLD method cannot reliably be applied.
与血氧水平依赖（BOLD）成像相比，评估在使用造影剂的情况下T1加权图像用于无磁化率伪影的功能图谱绘制的适用性。
6例患者和5名对照受试者在使用钆喷酸葡胺（Gd-DTPA）造影剂（TOFICA）的情况下接受了BOLD和T1加权功能成像扫描。在对照组中，进行了低分辨率和高分辨率的BOLD图像检查。功能刺激包括运动和语言激活。
BOLD和TOFICA方法均在预期的解剖区域产生了激活。与BOLD图像相比，TOFICA图谱的激活分布较少且信号变化百分比更高。注射后至少15分钟内，Gd-DTPA在血液中几乎保持恒定。在1例有手术夹的患者中，使用BOLD成像在左侧大脑半球未检测到信号，但使用TOFICA方法可绘制出激活情况。
使用造影剂的T1加权成像可用于功能图谱绘制。该方法对磁化率伪影不敏感，因此在术前病例评估以及BOLD方法无法可靠应用的靠近脑腔区域的评估中具有优势。
