Sugimoto Ken
Experimental Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.
World J Gastroenterol. 2008 Sep 7;14(33):5110-4. doi: 10.3748/wjg.14.5110.
Signal transducers and activators of transcription 3 (STAT3) play an important role in various autoimmune disorders including inflammatory bowel disease (IBD). Recent studies have revealed that STAT3 activation plays distinctly different roles between innate immune responses and acquired immune responses in colitis. STAT3-mediated activation of acquired immune responses plays a pathogenic role in colitis by enhancing the survival of pathogenic T cells. In contrast, STAT3-mediated activation of innate responses contributes to the suppression of colitis. This review will summarize the current understanding of the roles of STAT3 in IBD and the potential of targeting STAT3 for the treatment of IBD, emphasizing recent observations.
信号转导与转录激活因子3（STAT3）在包括炎症性肠病（IBD）在内的多种自身免疫性疾病中发挥着重要作用。最近的研究表明，STAT3激活在结肠炎的固有免疫反应和获得性免疫反应中发挥着截然不同的作用。STAT3介导的获得性免疫反应激活通过增强致病性T细胞的存活在结肠炎中发挥致病作用。相比之下，STAT3介导的固有反应激活有助于抑制结肠炎。本综述将总结目前对STAT3在IBD中的作用的理解以及靶向STAT3治疗IBD的潜力，重点介绍最近的观察结果。
