炎症性肠病中的Toll样受体——踏入未知领域
Toll-like receptors in inflammatory bowel disease-stepping into uncharted territory.
作者信息
Levin Avi, Shibolet Oren
机构信息
Liver Unit, Division of Medicine, POB 12000, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
出版信息
World J Gastroenterol. 2008 Sep 7;14(33):5149-53. doi: 10.3748/wjg.14.5149.
Abstract
Ulcerative colitis and Crohn's disease are chronic relapsing-remitting inflammatory processes of the intestinal tract. The etiology of these diseases is currently unknown. However, inflammation is hypothesized to result from inappropriate activation of mucosal immunity by luminal antigens in genetically susceptible individuals. Toll-like receptors (TLRs) are a family of transmembrane proteins that act as microbial pattern recognition receptors. They are crucial initiators of innate immune responses. The role of TLRs in the pathogenesis of inflammatory bowel disease (IBD) has not been fully elucidated. In this review, we aim to analyze the available data connecting individual TLRs to intestinal inflammation and IBD.
摘要
溃疡性结肠炎和克罗恩病是肠道的慢性复发性炎症过程。目前这些疾病的病因尚不清楚。然而，据推测，在基因易感个体中，炎症是由管腔抗原对黏膜免疫的不适当激活所致。Toll样受体（TLRs）是一类作为微生物模式识别受体的跨膜蛋白。它们是先天性免疫反应的关键启动因子。TLRs在炎症性肠病（IBD）发病机制中的作用尚未完全阐明。在本综述中，我们旨在分析将个体TLRs与肠道炎症和IBD联系起来的现有数据。
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