非移植患者中内镜联合熊去氧胆酸治疗胆泥综合征
Combined endoscopic and ursodeoxycholic acid treatment of biliary cast syndrome in a non-transplant patient.
作者信息
Katsinelos Panagiotis, Kountouras Jannis, Chatzimavroudis Grigoris, Zavos Christos, Pilpilidis Ioannis, Paroutoglou George
机构信息
Department of Endoscopy and Motility Unit, Central Hospital, and Department of Gastroenterology, Second Medical Clinic, Aristotle University of Thessaloniki, Ethnikis Aminis 41, Thessaloniki 54635, Greece.
出版信息
World J Gastroenterol. 2008 Sep 7;14(33):5223-5. doi: 10.3748/wjg.14.5223.
A 76-year-old diabetic man underwent cholecystectomy for gangrenous calculous cholecystitis. His postoperative course was complicated by the development of Candida albicans esophagitis necessitating antifungal therapy, and total parenteral nutrition (TPN) for 15 d. Seven weeks after cholecystectomy, he presented with cholangitis. Endoscopic retrograde cholangiopancreatography (ERCP) demonstrated extrahepatic filling defects. Despite endoscopic extraction of a biliary cast, cholestasis remained unchanged. Oral administration of ursodeoxycholic acid (UDCA), 750 mg/d, resulted in normalization of liver function tests. We, therefore, propose for the first time, combined endoscopic plus UDCA treatment for the management of biliary cast syndrome.
一名76岁的糖尿病男性因坏疽性结石性胆囊炎接受了胆囊切除术。他的术后病程因白色念珠菌食管炎的发生而复杂化，需要进行抗真菌治疗，并接受了15天的全胃肠外营养（TPN）。胆囊切除术后7周，他出现了胆管炎。内镜逆行胰胆管造影（ERCP）显示肝外充盈缺损。尽管通过内镜取出了胆管铸型，但胆汁淤积仍未改变。口服熊去氧胆酸（UDCA），750毫克/天，使肝功能检查恢复正常。因此，我们首次提出内镜联合UDCA治疗胆管铸型综合征。
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