新型咔唑基大环酰胺作为潜在抗菌剂的合成
Synthesis of novel carbazole based macrocyclic amides as potential antimicrobial agents.
作者信息
Rajakumar Perumal, Sekar Karuppannan, Shanmugaiah Vellasamy, Mathivanan Narayanasamy
机构信息
Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai, India.
出版信息
Eur J Med Chem. 2009 Jul;44(7):3040-5. doi: 10.1016/j.ejmech.2008.07.031. Epub 2008 Jul 31.
A series of carbazole based macrocyclic diamides with thia and oxy linkages have been synthesized and the inhibitory activity of the cyclophane amides against human pathogenic bacteria and plant pathogenic fungi are documented. (S)-1,10-Bi-2-naphthol [(S)-BINOL] based chiral carbazolophane amide emerged as the most interesting compound in this series exhibiting excellent antibacterial and antifungal activities.
一系列具有硫醚和氧醚键的咔唑基大环二酰胺已被合成，并且记录了环芳酰胺对人类病原菌和植物病原真菌的抑制活性。基于（S）-1,10-联-2-萘酚[（S）-BINOL]的手性咔唑环芳酰胺成为该系列中最有趣的化合物，表现出优异的抗菌和抗真菌活性。
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