咔唑衍生物作为潜在的抗菌剂。
Carbazole Derivatives as Potential Antimicrobial Agents.
机构信息
Department of Chemistry & Physics, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA.
Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
出版信息
Molecules. 2022 Oct 4;27(19):6575. doi: 10.3390/molecules27196575.
Microbial infection is a leading cause of death worldwide, resulting in around 1.2 million deaths annually. Due to this, medicinal chemists are continuously searching for new or improved alternatives to combat microbial infections. Among many nitrogen-containing heterocycles, carbazole derivatives have shown significant biological activities, of which its antimicrobial and antifungal activities are the most studied. In this review, miscellaneous carbazole derivatives and their antimicrobial activity are discussed (articles published from 1999 to 2022).
微生物感染是全球主要死因之一，每年导致约 120 万人死亡。因此，药物化学家一直在寻找新的或改进的方法来对抗微生物感染。在众多含氮杂环中，咔唑衍生物表现出显著的生物活性，其中其抗菌和抗真菌活性研究最多。在这篇综述中，讨论了各种咔唑衍生物及其抗菌活性（发表于 1999 年至 2022 年的文章）。
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