Papavasiliou Antigone S
Department of Neurology, Pendeli Children's Hospital, 8 Hippocrates street, Palia Pendeli, 15236, Athens, Greece.
Eur J Paediatr Neurol. 2009 Sep;13(5):387-96. doi: 10.1016/j.ejpn.2008.07.009. Epub 2008 Sep 7.
Currently there is no specific treatment for the brain insults leading to motor dysfunction in cerebral palsy. The available symptomatic therapeutic options place cerebral palsy among the costliest chronic childhood conditions. Therefore, it is necessary to make well-informed decisions in an effort to match cost-effectiveness with patient and family needs. This presentation aims to analyze the efficacy of rehabilitation therapy, orthoses, oral medications, botulinum toxin, intrathecal baclofen, complementary or alternative treatments and discuss guidelines for a goal oriented approach. Despite insufficient reporting of trials, physiotherapy has shifted from traditional to goal oriented approaches, based on principles of motor learning, strength and fitness training. Correct choice and use of orthoses is stressed, yet evidence from primary studies is limited. Pharmacological treatments of spasticity (oral agents, botulinum toxin, intrathecal baclofen) may be alternatives or supplements to orthopaedic surgery. There is evidence that botulinum toxin combined with conservative treatments reduces the number of complex orthopaedic interventions. Intrathecal baclofen effectively reduces spasticity; criteria describing the ideal candidate are needed. Complementary or alternative treatment use is widespread; research needs to determine what factors make these modalities desirable and effective in cerebral palsy. It is concluded that the introduction of new therapies facilitates an individualized management plan. Multimodal treatment is optimized with a multidisciplinary team. Outcome measurement according to the World Health Organization's new International Classification of Functioning, Disability and Health is emphasized.
目前,对于导致脑瘫运动功能障碍的脑损伤尚无特效治疗方法。现有的对症治疗方案使脑瘫成为最昂贵的儿童慢性疾病之一。因此,有必要做出明智的决策,努力使成本效益与患者及家庭需求相匹配。本报告旨在分析康复治疗、矫形器、口服药物、肉毒杆菌毒素、鞘内注射巴氯芬、补充或替代治疗的疗效,并讨论目标导向方法的指导原则。尽管试验报告不足,但物理治疗已从传统方法转向基于运动学习、力量和体能训练原则的目标导向方法。强调了矫形器的正确选择和使用,然而来自初步研究的证据有限。痉挛的药物治疗(口服药物、肉毒杆菌毒素、鞘内注射巴氯芬)可能是骨科手术的替代或补充方法。有证据表明,肉毒杆菌毒素与保守治疗相结合可减少复杂骨科手术的次数。鞘内注射巴氯芬可有效减轻痉挛;需要确定描述理想候选者的标准。补充或替代治疗的应用很广泛;研究需要确定哪些因素使这些方法在脑瘫治疗中具有可取性和有效性。得出的结论是,新疗法的引入有助于制定个性化的管理计划。多学科团队可优化多模式治疗。强调根据世界卫生组织新的《国际功能、残疾和健康分类》进行结果测量。