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[过量使用芬太尼透皮贴剂作为唯一的自杀手段]

[Excessive use of fentanyl patches as the only means of suicide].

作者信息

Wiesbrock Urs O, Rochholz Gertrud, Franzelius Cornelia, Schwark Thorsten, Grellner Wolfgang

机构信息

Institut für Rechtsmedizin des Universitätsklinikum Schleswig-Holstein.

出版信息

Arch Kriminol. 2008 Jul-Aug;222(1-2):23-30.

Abstract

Due to the increasing prescription there are more and more cases of abuse and accidents related to fentanyl patches. The use of fentanyl patches (e.g. Durogesic) for committing suicide is rare, however. In our case, we describe a suicide with an amount of fentanyl patches never mentioned in the literature before. A depressive 63-year-old man was found dead in his apartment. On the body of the decedent 20 nearly symmetrically arranged fentanyl patches (Durogesic) of different strength with a total dose of 1350 microg/h were found. According to the results of the police the fentanyl patches were part of the pain therapy of his late wife, who had died one year before. Neither the autopsy nor the histological examinations revealed a cause of death. The chemical-toxicological investigation showed the following fentanyl concentrations: 94.9 ng/g (femoral vein blood), 45.9 ng/g (blood of the left heart), 74.8 ng/g (blood of the right heart), 101 ng/mL (urine), 468 ng/mL (bile), 745 ng/mL (stomach contents), 78.4 ng/mL (cerebrospinal fluid), 133 ng/mL (vitreous humor). The blood concentrations were in the upper range of the concentrations found in similar cases published. Hints for a postmortem increase of the fentanyl concentration because of the long postmortem interval of nearly 8 days were found.

摘要

由于芬太尼透皮贴剂的处方量不断增加,与之相关的滥用和事故案例也越来越多。不过,使用芬太尼透皮贴剂(如多瑞吉)自杀的情况较为罕见。在我们这个案例中,我们描述了一起使用芬太尼透皮贴剂自杀的事件,其使用的贴剂数量在之前的文献中从未提及过。一名63岁患有抑郁症的男子被发现死于其公寓内。在死者尸体上发现了20片不同强度、近乎对称排列的芬太尼透皮贴剂(多瑞吉),总剂量为1350微克/小时。根据警方调查结果,这些芬太尼透皮贴剂是其亡妻(已于一年前去世)疼痛治疗用药的一部分。尸检和组织学检查均未发现死因。化学毒理学调查显示了以下芬太尼浓度:股静脉血94.9纳克/克、左心血45.9纳克/克、右心血74.8纳克/克、尿液101纳克/毫升、胆汁468纳克/毫升、胃内容物745纳克/毫升、脑脊液78.4纳克/毫升、玻璃体液133纳克/毫升。血液浓度处于已发表的类似案例中所发现浓度的上限范围。发现有迹象表明,由于近8天的较长死后间隔时间,芬太尼浓度在死后有所升高。

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