Fadda F, Garau B, Marchei F, Colombo G, Gessa G L
Institute of Human Physiology, University of Cagliari, Italy.
Alcohol Alcohol. 1991;26(2):107-10. doi: 10.1093/oxfordjournals.alcalc.a045088.
The effect of the selective 5-HT3 receptor antagonist MDL 72222 on voluntary ethanol consumption was examined in Sardinian ethanol-preferring (SP) rats in a free choice (10% ethanol and water) experiment. SP rats consumed 8.1 +/- 1.1 g/kg ethanol daily. MDL 72222 treatment (3.0, 5.0 and 7.0 mg/kg i.p. 3 times daily for 6 days) inhibited ethanol consumption during the 6 days of treatment by 25%, 50% and 75%, respectively, without modifying total fluid intake. We suggest that 5-HT3 receptor activation plays a permissive role in alcohol preference.
在一项自由选择（10%乙醇和水）实验中，研究了选择性5-羟色胺3（5-HT3）受体拮抗剂MDL 72222对撒丁岛嗜乙醇（SP）大鼠自愿乙醇摄入量的影响。SP大鼠每天摄入8.1±1.1克/千克乙醇。MDL 72222治疗（腹腔注射，剂量为3.0、5.0和7.0毫克/千克，每日3次，共6天）在治疗的6天内分别抑制乙醇摄入量25%、50%和75%，而不改变总液体摄入量。我们认为5-HT3受体激活在酒精偏好中起允许作用。
