[Effect of vasopressin and indomethacin on provoked diuresis in pregnant and non-pregnant Meriones crassus].

The dynamics of induced diuresis was studied in Meriones crassus, a desert rodent species, during estrus and pregnancy. In response to hydration, pregnant Meriones crassus excrete excess water more rapidly than non pregnant females. Diuresis appears earlier in pregnant females indicating a more rapid inactivation of vasopressin. The possible interaction between vasopressin and prostaglandins, and its effect on renal excretion during pregnancy, was studied during arginine-vasopressin treatment and after inhibition of endogenous AVP and prostaglandins. Results show a decrease in renal response to endogenous vasopressin during pregnancy in Meriones crassus, which may be due to the increase in renal prostaglandin levels.