社区中不同酒精摄入量的非裔美国人的铁转运蛋白Q248h、膳食铁与血清铁蛋白
Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption.
作者信息
Gordeuk Victor R, Diaz Sharmin F, Onojobi Gladys O, Kasvosve Ishmael, Debebe Zufan, Edossa Amanuel, Pantin Jeremy M, Xiong Shigang, Nekhai Sergei, Nouraie Mehdi, Tsukamoto Hidekazu, Taylor Robert E
机构信息
College of Medicine, Howard University, Washington, DC 20060, USA.
出版信息
Alcohol Clin Exp Res. 2008 Nov;32(11):1947-53. doi: 10.1111/j.1530-0277.2008.00782.x. Epub 2008 Sep 6.
BACKGROUND
Alcohol consumption is associated with increased iron stores. In sub-Saharan Africa, high dietary ionic iron and the ferroportin Q248H allele have also been implicated in iron accumulation. We examined the associations of ferroportin Q248H, alcohol and dietary iron with serum ferritin, aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT) concentrations in African-Americans.
METHODS
Inner-city African-Americans (103 men, 40 women) were recruited from the community according to reported ingestion of >4 alcoholic drinks/d or <2/wk. Typical daily heme iron, nonheme iron and alcohol were estimated using University of Hawaii's multiethnic dietary questionnaire. Based on dietary questionnaire estimates we established categories of < versus > or =56 g alcohol/d, equivalent to 4 alcoholic drinks/d assuming 14 g alcohol per drink.
RESULTS
Among 143 participants, 77% drank <56 g alcohol/d and 23%> or =56 g/d as estimated by the questionnaire. The prevalence of ferroportin Q248H was 23.3% with alcohol >56 g/d versus 7.5% with lower amounts (p = 0.014). Among subjects with no history of HIV disease, serum ferritin concentration had positive relationships with male gender (p = 0.041), alcohol consumption (p = 0.021) and ALT concentration (p = 0.0001) but not with dietary iron intake or ferroportin Q248H. Serum AST and ALT concentrations had significant positive associations with male gender and hepatitis C seropositivity but not with alcohol or dietary iron intake or ferroportin Q248H.
CONCLUSIONS
Our findings suggest a higher prevalence of ferroportin Q248H with greater alcohol consumption, and this higher prevalence raises the possibility that the allele might ameliorate the toxicity of alcohol. Our results suggest that alcohol but not dietary iron contributes to higher body iron stores in African-Americans. Studies with larger numbers of participants are needed to further clarify the relationship of ferroportin Q248H with the toxicity of alcohol consumption.
背景
饮酒与铁储存增加有关。在撒哈拉以南非洲地区，高膳食离子铁和铁转运蛋白Q248H等位基因也与铁蓄积有关。我们研究了铁转运蛋白Q248H、酒精和膳食铁与非裔美国人血清铁蛋白、天冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）浓度之间的关联。
方法
根据报告的每日饮酒量>4杯或每周<2杯，从社区招募市中心的非裔美国人（103名男性，40名女性）。使用夏威夷大学的多民族饮食问卷估计典型的每日血红素铁、非血红素铁和酒精摄入量。根据饮食问卷估计结果，我们将每日酒精摄入量分为<56克与>或=56克两类，假设每杯酒含14克酒精，则相当于每日4杯酒。
结果
在143名参与者中，根据问卷估计，77%的人每日饮酒量<56克，23%的人>或=56克。铁转运蛋白Q248H的患病率在酒精摄入量>56克/日的人群中为23.3%，而在酒精摄入量较低的人群中为7.5%（p = 0.014）。在无HIV疾病史的受试者中，血清铁蛋白浓度与男性性别（p = 0.041）、饮酒量（p = 0.021）和ALT浓度（p = 0.0001）呈正相关，但与膳食铁摄入量或铁转运蛋白Q248H无关。血清AST和ALT浓度与男性性别和丙型肝炎血清学阳性呈显著正相关，但与酒精或膳食铁摄入量或铁转运蛋白Q248H无关。
结论
我们的研究结果表明，铁转运蛋白Q248H的患病率在饮酒量较大的人群中较高，而这种较高的患病率增加了该等位基因可能减轻酒精毒性的可能性。我们的结果表明，在非裔美国人中，是酒精而非膳食铁导致了体内铁储存增加。需要更多参与者的研究来进一步阐明铁转运蛋白Q248H与饮酒毒性之间的关系。
Zotero 插件