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[单核细胞增生李斯特菌所致自然流产——三例报告]

[Spontaneus abortion caused by Listeria monocytogenes--report of three cases].

作者信息

Jezová M, Múcková K, Koukalová P

机构信息

Ustav patologie, Lékarská fakulta Masarykovy Univerzity a Fakultni nemocnice, Brno.

出版信息

Cesk Patol. 2008 Jul;44(3):71-4.

Abstract

This paper describes three cases of spontaneous abortion caused by Listeria monocytogenes which were diagnosed during the outbreak of listeriosis in late 2006. Both clinical and morphological features were highly consistent. The abortion between 19 and 20 weeks of gestation was preceded by high maternal fever. The fetal disease was miliary widespread with involvement of adrenals, liver and lungs in particular. There was always present a pustular rash. Histological examination of the placentas revealed acute chorioamnionitis with massive growth of gram-positive rods in the amnion in all cases. Acute villitis and intervillous microabscesses were additionally noted in one case. The diagnosis in all reported cases was not established until fetal autopsy. The final diagnosis was confirmed by microbiological examination using samples submitted during the autopsy examination.

摘要

本文描述了2006年末李斯特菌病暴发期间诊断出的3例由产单核细胞李斯特菌引起的自然流产病例。临床和形态学特征高度一致。妊娠19至20周时流产前孕妇出现高热。胎儿疾病呈粟粒性播散,尤其累及肾上腺、肝脏和肺。始终存在脓疱性皮疹。所有病例胎盘的组织学检查均显示急性绒毛膜羊膜炎,羊膜中有大量革兰氏阳性杆菌生长。1例还发现急性绒毛炎和绒毛间隙微脓肿。所有报告病例直至胎儿尸检才确诊。最终诊断通过尸检时提交的样本进行微生物学检查得以证实。

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