使用离子型Cp*Rh(III)催化剂对环状亚胺进行不对称氢化反应。

Asymmetric hydrogenation of cyclic imines with an ionic Cp*Rh(III) catalyst.

作者信息

Li Chaoqun, Xiao Jianliang

机构信息

Department of Chemistry, Liverpool Centre for Materials and Catalysis, University of Liverpool, Liverpool L69 7ZD, UK.

出版信息

J Am Chem Soc. 2008 Oct 8;130(40):13208-9. doi: 10.1021/ja8050958. Epub 2008 Sep 11.

DOI:10.1021/ja8050958

PMID:18783215

Abstract

When associated with a noncoordinating bulky counteranion, a cationic Cp*Rh(III)-diamine catalyst displayed excellent enantioselectivities in asymmetric hydrogenation of cyclic imines, affording bioactive tetrahydroisoquinolines and tetrahydro-beta-carbolines frequently with 99% ee's.

摘要

当与一个非配位的大体积抗衡阴离子结合时，一种阳离子型Cp*Rh(III)-二胺催化剂在环状亚胺的不对称氢化反应中表现出优异的对映选择性，经常以99%的对映体过量值得到生物活性的四氢异喹啉和四氢-β-咔啉。