Fallouh Hazem B, Chambers David J
Cardiac Surgical Research/Cardiothoracic Surgery, The Rayne Institute King's College London, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, London, UK.
Interact Cardiovasc Thorac Surg. 2008 Dec;7(6):1162-3. doi: 10.1510/icvts.2008.186494. Epub 2008 Sep 10.
The predominant method of myocardial protection during cardiac surgery is hyperkalaemic cardioplegia, inducing depolarised arrest. Since its development in the 1970s, the only real change has been to alter the vehicle to blood. Although blood cardioplegia was shown to be 'superior' to crystalloid cardioplegia, this advantage is marginal and might explain the continuous use of crystalloid cardioplegia by some surgeons. To achieve significant improvements in cardioplegic protection, more radical and conceptual changes in the solution, such as those potentially achieved by 'polarised' arrest, should be explored.
心脏手术期间心肌保护的主要方法是高钾停搏液，诱导去极化停搏。自20世纪70年代其发展以来，唯一真正的改变是将载体改为血液。尽管血液停搏液被证明比晶体停搏液“更优越”，但这种优势很微小，这或许可以解释一些外科医生仍持续使用晶体停搏液的原因。为了在停搏液保护方面取得显著改善，应该探索在溶液中进行更彻底和概念性的改变，比如那些可能通过“极化”停搏实现的改变。
