Furst D E
Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Rheumatology (Oxford). 2008 Oct;47 Suppl 5:v29-30. doi: 10.1093/rheumatology/ken269.
OMERACT (Outcome Measures in Rheumatologic Clinical Trials) is a loose organization of rheumatologists, epidemiologists and statisticians whose aim is to improve measurements in the rheumatic diseases. In this context, some SSc measures of response have been found to be valid: the modified Rodnan skin score, the Raynaud's condition score, the forced vital capacity as part of pulmonary function tests, right heart catheterization haemodynamics, serum creatinine, blood pressure and complete blood counts in scleroderma renal crisis and serum creatine phosphokinase as a measure of muscle disease in SSc. Other measures are being tested and have nearly been validated, including the gastrointestinal questionnaire in SSc. Finally, some measures have been found wanting or are not fully tested--in this case for pulmonary arterial hypertension, where effort is presently being focused. These include the echocardiogram, high-resolution CT scan of the lungs, pulmonary function tests, 6-min walking test and MRI.
OMERACT（风湿病临床试验中的疗效指标）是一个由风湿病学家、流行病学家和统计学家组成的松散组织，其目标是改进风湿病的测量方法。在此背景下，已发现一些系统性硬化症（SSc）的反应测量指标是有效的：改良Rodnan皮肤评分、雷诺现象评分、作为肺功能测试一部分的用力肺活量、右心导管血流动力学、血清肌酐、血压以及硬皮病肾危象时的全血细胞计数，还有血清肌酸磷酸激酶作为系统性硬化症肌肉疾病的一项测量指标。其他测量指标正在进行测试且几乎已得到验证，包括系统性硬化症的胃肠道问卷。最后，已发现一些测量指标存在不足或未得到充分测试——在肺动脉高压这种情况下，目前正在集中精力研究。这些指标包括超声心动图、肺部高分辨率CT扫描、肺功能测试、6分钟步行试验和磁共振成像。
