Moon Sunghyuk, Son Junhyuk, Chang Woohyok
Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea.
Korean J Ophthalmol. 2008 Sep;22(3):201-4. doi: 10.3341/kjo.2008.22.3.201.
We report a rare case of oculomotor nerve palsy and choroidal tuberculous granuloma associated with tuberculous meningoencephalitis. A 15-year-old male visited our hospital for an acute drop of the left eyelid and diplopia. He has been on anti-tuberculous drugs (isoniazid, rifampin) for 1 year for his tuberculous encephalitis. A neurological examination revealed a conscious clear patient with isolated left oculomotor nerve palsy, which manifested as ptosis, and a fundus examination revealed choroidal tuberculoma. Other anti-tuberculous drugs (pyrazinamide, ethambutol) and a steroid (dexamethasone) were added. After 3 months on this medication, ptosis of the left upper eyelid improved and the choroidal tuberculoma decreasedin size, but a right homonymous visual field defect remained. When a patient with tuberculous meningitis presents with abrupt onset oculomotor nerve palsy, rapid re-diagnosis should be undertaken and proper treatment initiated, because the prognosis is critically dependent on the timing of adequate treatment.
我们报告了一例罕见的动眼神经麻痹合并脉络膜结核性肉芽肿,与结核性脑膜脑炎相关。一名15岁男性因左眼睑急性下垂和复视前来我院就诊。他因结核性脑炎接受抗结核药物(异烟肼、利福平)治疗已1年。神经系统检查显示患者意识清醒,仅有孤立性左动眼神经麻痹,表现为上睑下垂,眼底检查发现脉络膜结核瘤。遂加用其他抗结核药物(吡嗪酰胺、乙胺丁醇)及一种类固醇药物(地塞米松)。服用此药物3个月后,左上睑下垂有所改善,脉络膜结核瘤体积减小,但仍遗留右侧同向性视野缺损。当结核性脑膜炎患者突然出现动眼神经麻痹时,应迅速重新诊断并开始适当治疗,因为预后严重依赖于充分治疗的时机。