生物医学检测与临床诊断中的分子信标
Molecular beacons in biomedical detection and clinical diagnosis.
作者信息
Kim Youngmi, Sohn Dosung, Tan Weihong
机构信息
Center for Research at the Bio/nano Interface, Department of Chemistry and UF Genetics Institute, Shands Cancer Center and McKnight Brain Institute, University of Florida Gainesville, FL, USA.
出版信息
Int J Clin Exp Pathol. 2008 Jan 1;1(2):105-16.
Abstract
Among the diverse nucleic acid probes, molecular beacons (MBs) have shown their excellent potential in a variety of basic researches and practical applications. Their excellent selectivity, sensitivity, and detection without separation have led them to be particularly useful in real-time intracellular monitoring of gene expression, development of biosensors, and clinical diagnostics. This paper will focus on the properties of various MBs and discuss their potential applications.
摘要
在各种核酸探针中，分子信标（MBs）在多种基础研究和实际应用中展现出了卓越的潜力。它们出色的选择性、灵敏度以及无需分离的检测方式，使其在基因表达的实时细胞内监测、生物传感器的开发以及临床诊断中特别有用。本文将聚焦于各种分子信标的特性，并探讨它们的潜在应用。
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