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[婴儿血管瘤的当前治疗方法:文献综述]

[Current treatment of infantile hemangiomas: an overview of the literature].

作者信息

Zheng Jia-wei, Ye Wei-min, Wang Yan-an, Zhou Guo-yu, Zhang Zhi-yuan

出版信息

Shanghai Kou Qiang Yi Xue. 2008 Aug;17(4):337-47.

Abstract

Hemangiomas are the most common neoplasm of infancy and childhood, about 40% to 60% of them involve the head and neck region. In recent years, many studies had been carried out on the natural course of hemangiomas, an algorithm for intervention versus observation was proposed, and effective safe treatment plan is devised. Close observation is indictable for hemangiomas which are remaining stable in size or in the involutive phase or post- involutive phase. For large hemangiomas, multiple hemangiomas, life-threatening hemangiomas and problematic hemangiomas with complications such as ulceration, infection, bleeding, dysfunction, etc, systematic drug therapy (Cortico steroids, interferon alpha-2a or 2b ) should be considered. Growing hemangioma can be treated effectively by systematic drug therapy, sclerotherapy, laser therapy or combined therapy. Topical application of imiquimoid and intratumoral injection of steroids or pinyangmycin can be used in selected patients with rapidly growing hemangioma. Surgery is no longer the first choice of treatment for hemangiomas, which is only reserved for correction of large residuals postinvolution.

摘要

血管瘤是婴幼儿期最常见的肿瘤,其中约40%至60%累及头颈部区域。近年来,针对血管瘤的自然病程开展了许多研究,提出了干预与观察的算法,并制定了有效安全的治疗方案。对于大小稳定或处于消退期或消退后期的血管瘤,密切观察是可行的。对于大型血管瘤、多发性血管瘤、危及生命的血管瘤以及伴有溃疡、感染、出血、功能障碍等并发症的疑难血管瘤,应考虑系统药物治疗(皮质类固醇、干扰素α-2a或2b)。生长中的血管瘤可通过系统药物治疗、硬化治疗、激光治疗或联合治疗有效治疗。咪喹莫特局部应用以及类固醇或平阳霉素瘤内注射可用于部分快速生长的血管瘤患者。手术不再是血管瘤治疗的首选,仅保留用于矫正消退后的大的残留病变。

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