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[高密度脂蛋白对凝血酶诱导的血小板聚集的影响]

[Effects of high-density lipoproteins on thrombin-induced platelet aggregation].

作者信息

Feoktistov I A, Vologushev S A, Karpov R S

出版信息

Biull Eksp Biol Med. 1991 May;111(5):485-6.

PMID:1878561
Abstract

Using new-developed method of aggregates radius measurement in suppression of washed human platelets, it has been shown, that HDL, in concentration of 190 ug/ml and in higher ones, totally inhibited aggregation, induced by 0.075 U/ml thrombin. For the same effect on aggregation, induced by 0.225 U/ml thrombin, HDL in concentration of 1320 ug/ml were needed.

摘要

采用新开发的在抑制洗涤后的人血小板聚集时测量聚集体半径的方法,结果表明,浓度为190微克/毫升及更高浓度的高密度脂蛋白(HDL)能完全抑制由0.075单位/毫升凝血酶诱导的聚集。对于由0.225单位/毫升凝血酶诱导的聚集产生相同的抑制效果,则需要浓度为1320微克/毫升的高密度脂蛋白。

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