Plattner Fabienne, Soldati-Favre Dominique
Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva CMU, 1211 Geneva 4, Switzerland.
Annu Rev Microbiol. 2008;62:471-87. doi: 10.1146/annurev.micro.62.081307.162802.
Intracellular pathogens such as viruses and bacteria subvert all the major cellular functions of their hosts. Targeted host processes include protein synthesis, membrane trafficking, modulation of gene expression, antigen presentation, and apoptosis. In recent years, it has become evident that protozoan pathogens, including members of the phylum Apicomplexa, also hijack their host cell's functions to access nutrients and to escape cellular defenses and immune responses. These obligate intracellular parasites provide superb illustrations of the subversion of host cell processes such as the recruitment and reorganization of host cell compartments without fusion around the parasitophorous vacuole of Toxoplasma gondii; the export of Plasmodium falciparum proteins on the surface of infected erythrocytes; and the induced transformation of the lymphocytes infected by Theileria parva, which leads to clonal extension.
诸如病毒和细菌之类的细胞内病原体破坏其宿主的所有主要细胞功能。靶向的宿主过程包括蛋白质合成、膜运输、基因表达调控、抗原呈递和细胞凋亡。近年来,越来越明显的是,包括顶复门成员在内的原生动物病原体也会劫持其宿主细胞的功能,以获取营养并逃避细胞防御和免疫反应。这些专性细胞内寄生虫极好地说明了宿主细胞过程的颠覆,例如在弓形虫的寄生泡周围不发生融合的情况下宿主细胞区室的募集和重组;恶性疟原虫蛋白质在受感染红细胞表面的输出;以及由小泰勒虫感染诱导的淋巴细胞转化,这导致克隆性扩增。
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