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Lymphocytic choriomeningitis virus-induced central nervous system disease: a model for studying the role of chemokines in regulating the acute antiviral CD8+ T-cell response in an immune-privileged organ.淋巴细胞性脉络丛脑膜炎病毒引起的中枢神经系统疾病:一种用于研究趋化因子在免疫豁免器官中调节急性抗病毒CD8 + T细胞反应作用的模型。
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CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system.CXCL10是CD8 +效应T细胞上CXCR3的关键配体,参与淋巴细胞性脉络丛脑膜炎病毒感染的中枢神经系统的免疫监视。
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Role of tumor necrosis factor receptors in regulating CD8 T-cell responses during acute lymphocytic choriomeningitis virus infection.肿瘤坏死因子受体在急性淋巴细胞性脉络丛脑膜炎病毒感染期间调节CD8 T细胞反应中的作用。
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Dynamics of the CD8+ T cell response during acute LCMV infection.急性淋巴细胞性脉络丛脑膜炎病毒感染期间CD8 + T细胞反应的动力学
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IRF9 Prevents CD8 T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection.在急性淋巴细胞性脉络丛脑膜炎病毒感染期间,IRF9以非内在方式预防CD8 T细胞耗竭。
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T cell responses to viral infections: lessons from lymphocytic choriomeningitis virus.T细胞对病毒感染的反应:来自淋巴细胞性脉络丛脑膜炎病毒的经验教训。
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PD-L1 Checkpoint Inhibition Narrows the Antigen-Specific T Cell Receptor Repertoire in Chronic Lymphocytic Choriomeningitis Virus Infection.PD-L1 检查点抑制缩小了慢性淋巴细胞脉络丛脑膜炎病毒感染中抗原特异性 T 细胞受体库。
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Agonistic anti-CD40 antibody profoundly suppresses the immune response to infection with lymphocytic choriomeningitis virus.激动性抗CD40抗体可显著抑制针对淋巴细胞性脉络丛脑膜炎病毒感染的免疫反应。
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Opposing effects of CXCR3 and CCR5 deficiency on CD8+ T cell-mediated inflammation in the central nervous system of virus-infected mice.CXCR3和CCR5缺陷对病毒感染小鼠中枢神经系统中CD8 + T细胞介导的炎症的相反作用。
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The numbers game for virus-specific CD8+ T cells.病毒特异性CD8+ T细胞的数字游戏。
Science. 1998 Apr 10;280(5361):227. doi: 10.1126/science.280.5361.227.

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Chemokine Signatures of Pathogen-Specific T Cells I: Effector T Cells.趋化因子谱的病原体特异性 T 细胞 I:效应 T 细胞。
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Local Antigen Encounter Is Essential for Establishing Persistent CD8 T-Cell Memory in the CNS.局部抗原接触对于在中枢神经系统中建立持久的 CD8 T 细胞记忆是必不可少的。
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Circumventricular Organs and Parasite Neurotropism: Neglected Gates to the Brain?室周器官与寄生虫嗜神经性:被忽视的脑“门户”?
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Is the concept of central nervous system immune privilege irrelevant in the setting of acute infection?在急性感染的情况下,中枢神经系统免疫豁免的概念是否无关紧要?
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Adaptive immune response to viral infections in the central nervous system.中枢神经系统对病毒感染的适应性免疫反应。
Handb Clin Neurol. 2014;123:225-47. doi: 10.1016/B978-0-444-53488-0.00010-9.
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Tryps and trips: cell trafficking across the 100-year-old blood-brain barrier.胰蛋白酶与旅行:细胞穿越百年血脑屏障的运输
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Passage of parasites across the blood-brain barrier.寄生虫穿过血脑屏障。
Virulence. 2012 Mar-Apr;3(2):202-12. doi: 10.4161/viru.19178. Epub 2012 Mar 1.
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Distinct Toll-like receptor signals regulate cerebral parasite load and interferon α/β and tumor necrosis factor α-dependent T-cell infiltration in the brains of Trypanosoma brucei-infected mice.不同的 Toll 样受体信号调节布氏锥虫感染小鼠脑中寄生虫负荷和干扰素 α/β 和肿瘤坏死因子 α 依赖性 T 细胞浸润。
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Microbes' roadmap to neurons.微生物通向神经元的道路。
Nat Rev Neurosci. 2011 Jun;12(6):345-57. doi: 10.1038/nrn3029. Epub 2011 May 18.
10
Inflammation in neuroviral diseases.神经病毒病中的炎症。
J Neural Transm (Vienna). 2010 Aug;117(8):899-906. doi: 10.1007/s00702-010-0402-y.

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Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.对同种异体移植皮肤的免疫;移植到脑、皮下组织和眼前房的同种异体皮肤的命运。
Br J Exp Pathol. 1948 Feb;29(1):58-69.
2
MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus.髓样分化因子88(MyD88)在感染水疱性口炎病毒期间可预防致死性脑炎。
Eur J Immunol. 2007 Sep;37(9):2434-40. doi: 10.1002/eji.200737310.
3
The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus.CD8 + T细胞对淋巴细胞性脉络丛脑膜炎病毒的反应涉及L抗原:揭示一种旧病毒的新把戏。
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4
Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought.定量淋巴细胞性脉络丛脑膜炎病毒特异性CD8 T细胞反应的强度:其比我们想象的还要强烈。
J Virol. 2007 Feb;81(4):2002-11. doi: 10.1128/JVI.01459-06. Epub 2006 Dec 6.
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5'-Triphosphate RNA is the ligand for RIG-I.5'-三磷酸核糖核酸是维甲酸诱导基因I(RIG-I)的配体。
Science. 2006 Nov 10;314(5801):994-7. doi: 10.1126/science.1132505. Epub 2006 Oct 12.
6
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.维甲酸诱导基因I(RIG-I)介导的对带有5'-磷酸基团的单链RNA的抗病毒反应。
Science. 2006 Nov 10;314(5801):997-1001. doi: 10.1126/science.1132998. Epub 2006 Oct 12.
7
Both CXCR3 and CXCL10/IFN-inducible protein 10 are required for resistance to primary infection by dengue virus.CXCR3和CXCL10/干扰素诱导蛋白10对于抵抗登革病毒的原发性感染均是必需的。
J Immunol. 2006 Aug 1;177(3):1855-63. doi: 10.4049/jimmunol.177.3.1855.
8
Essential role of IPS-1 in innate immune responses against RNA viruses.IPS-1在针对RNA病毒的天然免疫反应中的重要作用。
J Exp Med. 2006 Jul 10;203(7):1795-803. doi: 10.1084/jem.20060792. Epub 2006 Jun 19.
9
Neurons produce type I interferon during viral encephalitis.在病毒性脑炎期间,神经元会产生I型干扰素。
Proc Natl Acad Sci U S A. 2006 May 16;103(20):7835-40. doi: 10.1073/pnas.0602460103. Epub 2006 May 8.
10
Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction.趋化因子通过引导初始CD8 + T细胞至CD4 + T细胞与树突状细胞相互作用的部位来增强免疫力。
Nature. 2006 Apr 13;440(7086):890-5. doi: 10.1038/nature04651.

Lymphocytic choriomeningitis virus-induced central nervous system disease: a model for studying the role of chemokines in regulating the acute antiviral CD8+ T-cell response in an immune-privileged organ.

作者信息

Thomsen Allan Randrup

机构信息

Institute of International Health, Immunology, and Microbiology, University of Copenhagen, The Panum Institute, Building 22.5.18, 3C Blegdamsvej, DK-2200 Copenhagen N, Denmark.

出版信息

J Virol. 2009 Jan;83(1):20-8. doi: 10.1128/JVI.00682-08. Epub 2008 Sep 10.

DOI:10.1128/JVI.00682-08
PMID:18787010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2612318/
Abstract
摘要