Rosen Barry P, Liu Zijuan
Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA.
Environ Int. 2009 Apr;35(3):512-5. doi: 10.1016/j.envint.2008.07.023. Epub 2008 Sep 11.
Arsenic and selenium are metalloids found in the environment. Arsenic is considered to pose the most significant potential threat to human health based on frequency of occurrence, toxicity and human exposure. Selenium, on the other hand, ranks only 147th in toxicity but, in contrast to arsenic, is a required micronutrient. Whether a toxin or micronutrient, their metabolism requires that cells to accumulate these metalloids. In this review we discuss the membrane proteins that transport arsenic and selenium into cells, from bacteria to humans, as well as some of the efflux proteins involved in detoxification.
砷和硒是环境中发现的类金属。基于其出现频率、毒性和人类接触情况，砷被认为对人类健康构成最重大的潜在威胁。另一方面，硒的毒性仅排名第147位，但与砷不同的是，它是一种必需的微量营养素。无论作为毒素还是微量营养素，它们的代谢都需要细胞积累这些类金属。在这篇综述中，我们讨论了从细菌到人类将砷和硒转运到细胞内的膜蛋白，以及一些参与解毒的外排蛋白。
