砷和硒的转运途径：一篇综述短文
Transport pathways for arsenic and selenium: a minireview.
作者信息
Rosen Barry P, Liu Zijuan
机构信息
Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA.
出版信息
Environ Int. 2009 Apr;35(3):512-5. doi: 10.1016/j.envint.2008.07.023. Epub 2008 Sep 11.
Abstract
Arsenic and selenium are metalloids found in the environment. Arsenic is considered to pose the most significant potential threat to human health based on frequency of occurrence, toxicity and human exposure. Selenium, on the other hand, ranks only 147th in toxicity but, in contrast to arsenic, is a required micronutrient. Whether a toxin or micronutrient, their metabolism requires that cells to accumulate these metalloids. In this review we discuss the membrane proteins that transport arsenic and selenium into cells, from bacteria to humans, as well as some of the efflux proteins involved in detoxification.
摘要
砷和硒是环境中发现的类金属。基于其出现频率、毒性和人类接触情况，砷被认为对人类健康构成最重大的潜在威胁。另一方面，硒的毒性仅排名第147位，但与砷不同的是，它是一种必需的微量营养素。无论作为毒素还是微量营养素，它们的代谢都需要细胞积累这些类金属。在这篇综述中，我们讨论了从细菌到人类将砷和硒转运到细胞内的膜蛋白，以及一些参与解毒的外排蛋白。
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本文引用的文献
1
THE EFFECT OF ARSENIC ON THE TOXICITY OF SELENIFEROUS GRAINS.砷对富硒谷物毒性的影响
Science. 1938 Jul 22;88(2273):81. doi: 10.1126/science.88.2273.81.
2
Market basket survey shows elevated levels of As in South Central U.S. processed rice compared to California: consequences for human dietary exposure.市场篮子调查显示，与加利福尼亚州相比，美国中南部加工大米中的砷含量较高：对人类膳食暴露的影响。
Environ Sci Technol. 2007 Apr 1;41(7):2178-83. doi: 10.1021/es061489k.
3
Sulfate transport in Aspergillus nidulans: a novel gene encoding alternative sulfate transporter.构巢曲霉中的硫酸盐转运：一个编码替代性硫酸盐转运蛋白的新基因。
Fungal Genet Biol. 2007 Aug;44(8):715-25. doi: 10.1016/j.fgb.2006.11.007. Epub 2007 Jan 16.
4
Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid.哺乳动物葡萄糖转运蛋白GLUT1促进三氧化二砷和甲基亚砷酸的转运。
Biochem Biophys Res Commun. 2006 Dec 15;351(2):424-30. doi: 10.1016/j.bbrc.2006.10.054. Epub 2006 Oct 17.
5
An arsenic metallochaperone for an arsenic detoxification pump.一种用于砷解毒泵的砷金属伴侣蛋白。
Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15617-22. doi: 10.1073/pnas.0603974103. Epub 2006 Oct 9.
6
Selenium in cancer prevention: a review of the evidence and mechanism of action.硒在癌症预防中的作用：证据及作用机制综述
Proc Nutr Soc. 2005 Nov;64(4):527-42. doi: 10.1079/pns2005467.
7
The kinetics of 75[Se]-selenite uptake by Saccharomyces cerevisiae and the vacuolization response to high concentrations.酿酒酵母对75[硒]亚硒酸盐的摄取动力学以及对高浓度的液泡化反应。
Mycol Res. 2004 Dec;108(Pt 12):1415-22. doi: 10.1017/s0953756204001418.
8
Toenail arsenic content and cutaneous melanoma in Iowa.爱荷华州的趾甲砷含量与皮肤黑色素瘤
Am J Epidemiol. 2004 Oct 1;160(7):679-87. doi: 10.1093/aje/kwh267.
9
Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin.水甘油通道蛋白对利什曼原虫药物摄取及耐药性的调节
J Biol Chem. 2004 Jul 23;279(30):31010-7. doi: 10.1074/jbc.M403959200. Epub 2004 May 11.
10
Experimental and theoretical characterization of arsenite in water: insights into the coordination environment of As-O.水中亚砷酸盐的实验与理论表征：对As-O配位环境的见解
Inorg Chem. 2004 May 3;43(9):2954-9. doi: 10.1021/ic0351592.
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