Klechevsky Eynav, Morita Rimpei, Liu Maochang, Cao Yanying, Coquery Sebastien, Thompson-Snipes Luann, Briere Francine, Chaussabel Damien, Zurawski Gerard, Palucka A Karolina, Reiter Yoram, Banchereau Jacques, Ueno Hideki
Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA.
Immunity. 2008 Sep 19;29(3):497-510. doi: 10.1016/j.immuni.2008.07.013.
Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LCs preferentially induced the differentiation of CD4(+) T cells secreting T helper 2 (Th2) cell cytokines and were efficient at priming and crosspriming naive CD8(+) T cells. A third DC population, CD14(-)CD207(-)CD1a(+) DC, which resides in the dermis, could activate CD8(+) T cells better than CD14(+) DCs but less efficiently than LCs. Thus, the human skin displays three DC subsets, two of which, i.e., CD14(+) DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively.
关于人类皮肤髓样树突状细胞（DC）亚群、表皮CD207(+)朗格汉斯细胞（LC）和真皮CD14(+) DC之间的功能差异，人们了解甚少。我们发现，CD14(+) DC将CD4(+) T细胞诱导分化为能促使未成熟B细胞发生同种型转换并成为浆细胞的细胞。相比之下，LC优先诱导分泌辅助性T细胞2（Th2）细胞因子的CD4(+) T细胞分化，并且在启动和交叉启动未成熟CD8(+) T细胞方面效率很高。存在于真皮中的第三种DC群体，即CD14(-)CD207(-)CD1a(+) DC，比CD14(+) DC能更好地激活CD8(+) T细胞，但效率低于LC。因此，人类皮肤有三种DC亚群，其中两种，即CD14(+) DC和LC，分别表现出功能特异性，即优先激活体液免疫和细胞免疫。
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