CD1a与脂质作为皮肤中T细胞活化的介质
CD1a and Lipids as Mediators of T Cell Activation in the Skin.
作者信息
Fahmy Lauren M, Adeuyan Oluwaseyi O, de Jong Annemieke
机构信息
Department of Dermatology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.
Department of Dermatology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.
出版信息
J Invest Dermatol. 2025 May 3. doi: 10.1016/j.jid.2025.03.020.
Despite increasing insights in cytokine pathways involved in T cell-mediated inflammatory skin diseases, the upstream T cell triggering events through antigen-presenting molecules and antigens often remain incompletely understood. Recent studies have proposed an immunopathogenic role for T cells that are activated through CD1a, a lipid antigen-presenting molecule abundantly expressed on antigen-presenting cells in human skin. These CD1a-restricted T cells are thought to play a role in psoriasis, atopic dermatitis, and allergic contact dermatitis. In this review, we discuss modes of T cell activation by CD1a proteins and lipid antigens and bacteria as well as recent insights in local and systemic functions of CD1a-restricted T cells in inflammatory skin disease.
尽管对参与T细胞介导的炎症性皮肤病的细胞因子途径有了越来越多的认识，但通过抗原呈递分子和抗原引发T细胞的上游事件往往仍未完全了解。最近的研究提出，通过CD1a激活的T细胞具有免疫致病作用，CD1a是一种在人类皮肤的抗原呈递细胞上大量表达的脂质抗原呈递分子。这些受CD1a限制的T细胞被认为在银屑病、特应性皮炎和过敏性接触性皮炎中起作用。在这篇综述中，我们讨论了CD1a蛋白、脂质抗原和细菌激活T细胞的模式，以及对炎症性皮肤病中受CD1a限制的T细胞的局部和全身功能的最新认识。
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