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响应调节因子YycF对细菌生长至关重要：DNA结合结构域的X射线晶体结构及其类PhoB DNA识别基序

Response regulator YycF essential for bacterial growth: X-ray crystal structure of the DNA-binding domain and its PhoB-like DNA recognition motif.

作者信息

Okajima Toshihide, Doi Akihiro, Okada Ario, Gotoh Yasuhiro, Tanizawa Katsuyuki, Utsumi Ryutaro

机构信息

Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan.

出版信息

FEBS Lett. 2008 Oct 15;582(23-24):3434-8. doi: 10.1016/j.febslet.2008.09.007. Epub 2008 Sep 26.

DOI:10.1016/j.febslet.2008.09.007
PMID:18789936
Abstract

A response regulator YycF and its cognate sensor kinase YycG constitute the two-component signal transduction system essential for growth of Gram-positive bacteria with a low GC content. We have determined the X-ray crystal structure of the effector domain of Bacillus subtilis YycF involved in DNA binding. The structure, containing a winged helix-turn-helix motif, was found to be very similar to that of the response regulator PhoB from Escherichia coli. Specific binding of YycF to the PhoB-regulated alkaline phosphatase promoter was also demonstrated.

摘要

应答调节蛋白YycF及其同源传感激酶YycG构成了低GC含量革兰氏阳性菌生长所必需的双组分信号转导系统。我们已经确定了参与DNA结合的枯草芽孢杆菌YycF效应结构域的X射线晶体结构。该结构包含一个带翼的螺旋-转角-螺旋基序，发现它与大肠杆菌的应答调节蛋白PhoB的结构非常相似。还证明了YycF与PhoB调节的碱性磷酸酶启动子的特异性结合。

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