Takahashi Hidetoshi, Iwase Masao, Ishii Ryouhei, Ohi Kazutaka, Fukumoto Motoyuki, Azechi Michiyo, Ikezawa Koji, Kurimoto Ryu, Canuet Leonides, Nakahachi Takayuki, Iike Naomi, Tagami Shinji, Morihara Takashi, Okochi Masayasu, Tanaka Toshihisa, Kazui Hiroaki, Yoshida Tetsuhiko, Tanimukai Hitoshi, Yasuda Yuka, Kudo Takashi, Hashimoto Ryota, Takeda Masatoshi
Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Neurosci Res. 2008 Nov;62(3):187-94. doi: 10.1016/j.neures.2008.08.006. Epub 2008 Aug 26.
Prepulse inhibition (PPI) and habituation of the acoustic startle reflex (ASR) are considered to be candidate endophenotypes of schizophrenia. However, to our knowledge, only one group has investigated these startle measures in Asian patients with schizophrenia. In the present study, we evaluated these startle measures in 51 Japanese patients with schizophrenia and compared them with those of 55 healthy age- and sex-matched Japanese controls. A human startle response monitoring system was used to deliver acoustic startle stimuli, and record and score the electromyographic activity of the orbicularis oculi muscle. The startle measures examined were mean magnitude of ASR to pulse alone trials in initial block (SR), habituation of ASR during the session (HAB), and PPI at prepulse intensities of 82 dB (PPI82), 86 dB (PPI86), and 90 dB (PPI90) sound pressure level. SR was not significantly different between the patients and controls. Patients displayed significantly reduced HAB and PPI for all prepulse intensities compared to controls. The greatest statistical difference in PPI between patients and controls was found with PPI86. This did not correlate with any clinical variable in each group. Our results indicate that PPI and habituation of ASR are impaired in Asian patients with schizophrenia.
前脉冲抑制（PPI）和听觉惊吓反射（ASR）的习惯化被认为是精神分裂症的候选内表型。然而，据我们所知，只有一组研究人员对亚洲精神分裂症患者的这些惊吓指标进行了调查。在本研究中，我们评估了51名日本精神分裂症患者的这些惊吓指标，并将其与55名年龄和性别匹配的健康日本对照者的指标进行了比较。使用人体惊吓反应监测系统来施加听觉惊吓刺激，并记录和评分眼轮匝肌的肌电活动。所检查的惊吓指标包括初始组块中仅对脉冲试验的ASR平均幅度（SR）、试验期间ASR的习惯化（HAB）以及在82分贝（PPI82）、86分贝（PPI86）和90分贝（PPI90）声压级的前脉冲强度下的PPI。患者和对照者之间的SR没有显著差异。与对照者相比，患者在所有前脉冲强度下的HAB和PPI均显著降低。患者和对照者之间PPI的最大统计学差异出现在PPI86时。这与每组中的任何临床变量均无相关性。我们的结果表明，亚洲精神分裂症患者的PPI和ASR习惯化受损。
