Pongjanyakul Thaned
Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
Int J Pharm. 2009 Jan 5;365(1-2):100-8. doi: 10.1016/j.ijpharm.2008.08.025. Epub 2008 Aug 27.
Sodium alginate-magnesium aluminum silicate (SA-MAS) composite dispersions were prepared and characterized for the flow behavior and morphology of their dispersed phase before casting. The high G block and high M block SA (GSA and MSA, respectively) were used. The physicochemical properties and permeabilities of the films were investigated using non-electrolyte and amine compounds in an acidic medium. The results showed that incorporation of MAS into the GSA and MSA dispersions gave identical flow behaviors and morphologies of MAS flocculates. FTIR spectroscopy revealed that the GSA and MSA presented similar molecular interactions with MAS in the films. However, the crystallinity of the GSA-MAS films was possibly higher than that of the MSA-MAS films. This indicated a higher density of matrix structure formed between GSA and MAS, resulting in lower water uptake in an acidic medium. Consequently, the permeability of the GSA-MAS films was lower than that of the MSA-MAS films. The diffusion and partition coefficients were directly related to the molecular weight of the non-electrolyte and amine compounds. This study suggested that transport of non-electrolyte compounds was predominantly controlled by diffusion in aqueous-filled microchannels, whereas both partition via adsorption onto MAS and diffusion in microchannels occurred concurrently for amine compounds.
制备了海藻酸钠-硅酸镁铝（SA-MAS）复合分散体，并对其在浇铸前分散相的流动行为和形态进行了表征。使用了高G嵌段和高M嵌段的SA（分别为GSA和MSA）。在酸性介质中，使用非电解质和胺类化合物研究了薄膜的物理化学性质和渗透性。结果表明，将MAS加入到GSA和MSA分散体中，MAS絮凝物具有相同的流动行为和形态。傅里叶变换红外光谱表明，GSA和MSA在薄膜中与MAS呈现相似的分子相互作用。然而，GSA-MAS薄膜的结晶度可能高于MSA-MAS薄膜。这表明GSA和MAS之间形成的基体结构密度更高，导致在酸性介质中的吸水率更低。因此，GSA-MAS薄膜的渗透性低于MSA-MAS薄膜。扩散系数和分配系数与非电解质和胺类化合物的分子量直接相关。该研究表明，非电解质化合物的传输主要受充满水的微通道中扩散的控制，而胺类化合物则同时发生通过吸附到MAS上的分配和在微通道中的扩散。
