Sakai K, Okamoto M, Suzuki T, Yoshizawa A, Nobori S, Ushigome H, Sakamoto S, Akioka K, Kaihara S, Yoshimura N
Department of Transplantation and Regenerative Surgery, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Transplant Proc. 2008 Sep;40(7):2118-20. doi: 10.1016/j.transproceed.2008.07.072.
In coping with the shortage of deceased kidney donors, living donor kidney transplantation is mainly performed in Japan. We started our living unrelated spousal kidney transplantation program in 1989. In this analysis, we compared the results of 64 spousal transplantations performed between September 1989 and May 2007 with those of living related and deceased donor grafts. Despite the older age of the recipients and the lower HLA matching, the graft survival rates of spousal transplants were as good as those from living related donors and better than those from deceased donors, (P < .01). The graft survival rate of spousal kidney transplantation is improving with advances in immunosuppression, so spouses are considered important donors in Japan, which lacks deceased donors.
为应对已故肾供体短缺的问题，日本主要开展活体供肾移植。我们于1989年启动了非亲属活体配偶肾移植项目。在本分析中，我们将1989年9月至2007年5月期间进行的64例配偶肾移植结果与活体亲属供肾和已故供肾移植结果进行了比较。尽管受者年龄较大且HLA配型较低，但配偶肾移植的移植物存活率与活体亲属供肾的存活率相当，且优于已故供肾移植的存活率（P <.01）。随着免疫抑制技术的进步，配偶肾移植的移植物存活率正在提高，因此在缺乏已故供体的日本，配偶被视为重要的供体。
