Amante A J, Ejercito R
Capitol Medical Center, Quezon City, Philippines.
Transplant Proc. 2008 Sep;40(7):2274-80. doi: 10.1016/j.transproceed.2008.07.007.
Highly sensitized patients with elevated anti-HLA antibodies have difficulty to get a living donor due to cross-match positivity and longer waiting times for cadaveric donor transplantation. In this regard, several studies have been made to abrogate cross-match positivity for a possible successful kidney transplantation. In this article, we report our experience, using a desensitization protocol with Rituximab monoclonal antibody complemented with intravenous immunoglubulin and/or plasmapheresis, to prepare highly sensitized patients for successful kidney transplantation.
具有高滴度抗人白细胞抗原（HLA）抗体的高敏患者，由于交叉配型阳性以及尸体供体移植等待时间较长，很难获得活体供体。在这方面，已经开展了多项研究以消除交叉配型阳性，从而实现可能成功的肾移植。在本文中，我们报告了我们的经验，即使用利妥昔单抗单克隆抗体脱敏方案，并辅以静脉注射免疫球蛋白和/或血浆置换，为高敏患者成功进行肾移植做准备。
