Ye D, Han D Y, Wang J R
Xuan-Wu Hospital, Capital Institute of Medicine, Beijing.
Zhong Xi Yi Jie He Za Zhi. 1991 May;11(5):289-90, 262.
Using electromechanical transducer and conventional microelectrodes in isolated guinea pig heart muscles, the effects of ursodeoxycholic acid (UDCA) on the mechanical and electric activities were firstly observed. The results showed that, UDCA in dose of 0.05 mg/ml decreased contractile force by 36% (P less than 0.001) and shortened action potential duration (n = 3). It is inferred that UDCA may block inward calcium current. The results suggest that the action of UDCA is similar to that of bear bile and may be an effective composition of bear bile which acts on heart muscle. Our findings provide the experimental basis for the clinical application of UDCA.
在豚鼠离体心肌中使用机电换能器和传统微电极，首次观察了熊去氧胆酸（UDCA）对机械和电活动的影响。结果表明，0.05mg/ml剂量的UDCA使收缩力降低了36%（P<0.001），并缩短了动作电位时程（n = 3）。推测UDCA可能阻断内向钙电流。结果提示，UDCA的作用与熊胆相似，可能是熊胆作用于心肌的有效成分。我们的研究结果为UDCA的临床应用提供了实验依据。
