Militello Kevin T, Wang Ping, Jayakar Sangeeta K, Pietrasik Rebecca L, Dupont Christopher D, Dodd Kristi, King Anthony M, Valenti Paul R
Department of Biology, State University of New York at Geneseo, Geneseo, NY 14454, USA.
Eukaryot Cell. 2008 Nov;7(11):2012-6. doi: 10.1128/EC.00198-08. Epub 2008 Sep 12.
It is currently unclear if there are modified DNA bases in Trypanosoma brucei other than J-base. We identify herein a cytosine-5 DNA methyltransferase gene and report the presence and location of 5-methylcytosine in genomic DNA. Our data demonstrate that African trypanosomes contain a functional cytosine DNA methylation pathway.
目前尚不清楚布氏锥虫中除J碱基外是否存在其他修饰的DNA碱基。我们在此鉴定出一个5-胞嘧啶DNA甲基转移酶基因,并报告基因组DNA中5-甲基胞嘧啶的存在及其位置。我们的数据表明,非洲锥虫含有一条功能性的胞嘧啶DNA甲基化途径。