Kliegman R M, Clapp D W
Case Western Reserve University School of Medicine, Cleveland, Ohio.
Clin Perinatol. 1991 Jun;18(2):303-24.
Immunotherapy was a common method of treating infectious diseases in the preantibiotic era. Serotherapy was a popular approach to serious infections and employed hyperimmune globulins harvested from various large animals. Such antisera needed to be administered early in the course of the disease and unfortunately was associated with significant risks of anaphylaxis and serum sickness. Because of the allergic risks associated with animal immunoglobulin preparations, the development of methods to isolate human immunoglobulins heralded a new era in immunotherapy. This article examines the uses of immunotherapy in the treatment of neonatal infections.
免疫疗法是抗生素时代之前治疗传染病的常用方法。血清疗法是治疗严重感染的一种流行方法，使用从各种大型动物身上采集的超免疫球蛋白。这种抗血清需要在疾病过程早期给药，不幸的是，它与过敏反应和血清病的重大风险相关。由于动物免疫球蛋白制剂存在过敏风险，分离人免疫球蛋白方法的发展开创了免疫疗法的新时代。本文探讨免疫疗法在新生儿感染治疗中的应用。
